弹状病毒基质蛋白(Matrix protein)的研究进展

福建农业学报 ›› 2011, Vol. ›› Issue (1): 130-134.

弹状病毒基质蛋白(Matrix protein)的研究进展

杨振慧^1,2, 葛均青², 龚晖², 林天龙²

1. 福建师范大学生命科学学院, 福建, 福州, 350108;
2. 福建省农业科学院生物技术研究所, 福建, 福州, 350003

收稿日期:2010-10-02 修回日期:2011-01-19 出版日期:2011-02-15 发布日期:2011-02-15
通讯作者: 林天龙(1955-),男,研究员,主要从事水产保护学研究(E-mail:Lint05@163.com)
基金资助:
福建省自然科学基金(2009J01090);福建省青年科技人才创新项目(2008F3018);福建省属公益类科研院所基本科研专项(2009R10035-6)

Advances in research on rhabdovirus matrix protein

YANG Zhen-hui^1,2, GE Jun-qing², Gong Hui², LIN Tian-long²

1. Department of Life Science, Fujian Normal University, Fuzhou, Fujian 350108, China;
2. Institute of Biotechnology, Fujian Academy of Agricultural Sciences, Fuzhou, Fujian 350003, China

Received:2010-10-02 Revised:2011-01-19 Online:2011-02-15 Published:2011-02-15

摘要/Abstract

摘要： 弹状病毒的基因组由1段线性单股不分节的负链RNA组成,主要编码5个结构蛋白,分别为核蛋白(Nucleoprotein,N)、磷蛋白(Phosphoprotein,P)、基质蛋白(Matrix protein,M)、糖蛋白(Glycoprotein,G)和RNA聚合酶(RNA polymerase,L)。其中,基质蛋白(M)是一种多功能性蛋白,在病毒的侵染过程中参与病毒粒子的出芽、装配,抑制核质运输,调控宿主的基因转录,诱导细胞凋亡等。本文综述M蛋白的研究进展。

关键词: 弹状病毒, 基质蛋白, 结构, 功能, 应用

Abstract: Rhabdovirus contains a linear,negative-sense and single-stranded RNA genome.It encodes 5 structural proteins,including nucleoprotein(N),phosphoprotein(P),matrix protein(M),glycoprotein(G) and RNA polymerase(L).The matrix protein takes multi-function in the virus infection cycle,including participating in virus budding and assembly,inhibiting protein nucleocytoplasmic transport,and regulating host gene transcription and inducing cell apoptosis.Recent advances in the research on the matrix protein are reviewed.

Key words: rhabdovirus, matrix protein, structure, function, application

中图分类号:

S917

杨振慧, 葛均青, 龚晖, 林天龙. 弹状病毒基质蛋白(Matrix protein)的研究进展[J]. 福建农业学报, 2011, (1): 130-134.

YANG Zhen-hui, GE Jun-qing, Gong Hui, LIN Tian-long. Advances in research on rhabdovirus matrix protein[J]. Fujian Journal of Agricultural Sciences, 2011, (1): 130-134.

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